wikis   quiz   map   search the full wiki search: more info on acute intermittent porphyria   wikis encyclopedia mechanism of disease treatment famous sufferers cultural references references see also related links related topics   quiz quiz   map maps related topics list of rare diseases starting with f list of rare diseases starting with m alexander disease list of rare diseases starting with a christopher logue abdominal aortic aneurysm acute intermittent porphyria: wikis       note: many of our articles have direct quotes from sources you can cite, within the wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles. buy viagra online Related top topics abdominal aortic aneurysm categories: skin conditions resulting from errors in metabolism > rare diseases > genetic disorders > porphyrias encyclopedia updated live from wikipedia, last check: october 09, 2012 04:47 utc (35 seconds ago) from wikipedia, the free encyclopedia acute intermittent porphyria classification and external resources porphobilinogen icd-10 e 80. viagra soft tabs 10 mg 2 icd-9 277. 1 omim 176000 diseasesdb 171 emedicine med/1880 mesh d017118 acute intermittent porphyria (aip) is a rare autosomal dominant [1] metabolic disorder affecting the production of heme, the oxygen-binding prosthetic group of hemoglobin. generic viagra reviews It is characterized by a deficiency of the enzyme porphobilinogen deaminase. cheap viagra online Acute intermittent porphyria is the second most common form of porphyria. cheap viagra [2] :525 contents 1 mechanism of disease 2 treatment 3 famous sufferers 4 cultural references 5 references 6 see also mechanism of disease under normal circumstances, heme synthesis begins in the mitochondrion, proceeds into the cytoplasm, and finishes back in the mitochondrion. However, without porphobilinogen deaminase, a necessary cytoplasmic enzyme, heme synthesis cannot finish, and the metabolite porphobilinogen accumulates in the cytoplasm. [3] additional factors must also be present such as hormones, drugs, and dietary changes that trigger the appearance of symptoms. 20 mg viagra instructions Symptoms of aip may include abdominal pain, constipation, and muscle weakness. order viagra Treatment a high-carbohydrate a glucose 10% infusion is recommended, which may aid in recovery. 20 mg viagra instructions If drugs have caused the attack, discontinuing the offending substances is essential. Infection is one of the top causes of attacks and requires vigorous treatment. Pain is extremely severe and almost always requires the use of opiates to reduce it to tolerable levels. Pain should be treated early as medically possible due to its severity. Nausea can be severe; it may respond to phenothiazine drugs but is sometimes intractable. Hot water baths or showers may lessen nausea temporarily, but can present a risk of burns or falls. [4] hematin and heme arginate are the drugs of choice in a. order viagra online viagra time between.doses